The vibrant equilibrium of our body, especially the skeletal system, is intricately shaped by the dynamic interplay of the gut microbiota. Antibiotics can directly or indirectly impact the skeletal system by influencing the microbiota. In situations of estrogen deficiency, probiotic bacteria have been documented to impact bone health positively. The relationship between antibiotics, the gut microbiota, and bone health is a complex and developing field of research. This study aims to regulate the in vitro release of azithromycin (AZM) and address challenges linked to oral administration of AZM for influencing gut microbiota and enhancing bone healing. In pursuit of this objective, we formulated AZM-loaded polylactic acid/hydroxyapatite (PLA/HAp) composite microspheres using the double emulsion solvent evaporation technique. The impact of varying HAp contents on the morphology and release profile of PLA/HAp microspheres was also evaluated. The morphology and size of the AZM-loaded microspheres were examined using a high-resolution scanning electron microscope (SEM). The prepared microspheres had a spherical morphology and average particle size of 58.585 µm to 120 µm. Mathematical modelling was conducted to predict the release mechanism of AZM from the composite microspheres. The in vitro AZM release confirmed the reduction of initial burst release from the composite microspheres compared to PLA microspheres and commercially available AZM tablets.


    Access

    Check access

    Check availability in my library

    Order at Subito €


    Export, share and cite



    Title :

    Sustained Azithromycin Release via Hydroxyapatite-Polylactic Acid Composite Microspheres


    Additional title:

    Mechan. Machine Science



    Conference:

    Conference on Microactuators and Micromechanisms ; 2024 ; Ho Chi Minh City, Vietnam November 09, 2024 - November 11, 2024



    Publication date :

    2025-03-08


    Size :

    16 pages





    Type of media :

    Article/Chapter (Book)


    Type of material :

    Electronic Resource


    Language :

    English




    Polylactic acid composite board and preparation method thereof

    YANG TIANBO / LUO HAO / FAN XILONG et al. | European Patent Office | 2023

    Free access

    Easily degradable polylactic acid automobile foot mat

    LIN XIAO / XU BIN / YING XIA et al. | European Patent Office | 2023

    Free access

    Preliminary investigations of polylactic acid (PLA) properties

    Subramaniam, S. R. / Samykano, M. / Selvamani, S. K. et al. | American Institute of Physics | 2019


    Biodegradable polylactic acid microstructures for scaffold applications

    Wang, G. J. / Ho, K. H. / Hsueh, C. C. | British Library Online Contents | 2008