Abstract In the course of experimental approach to the chemical evolution in the primeval sea, we have found that the main products from formaldehyde and hydroxylamine are glycine, alanine, serine, aspartic acid etc., and the products from glycine and formaldehyde are serine and aspartic acid. Guanine is found in the two-letter genetic codons of all these amino acids. Based upon the finding and taking into consideration the probable synthetic pathways of nucleotide bases and protein amino acids in the course of chemical evolution and a correlation between the two-letter codons and the number of carbon atoms in the carbon skeleton of amino acids, 1 have been led to a working hypothesis on the interdependent genesis of nucleotide bases, protein amino acids, and primitive genetic code as shown in Table I. Protein amino acids can be classified into two groups: Purine Group amino acids and Pyrimidine Group amino acids. Purine bases and Pyrimidine bases are predominant in two-letter codons of amino acids belonging to the former and the latter group respectively. Guanine, adenine, and amino acids of the Purine Group may be regarded as synthesized from $ C_{1} $ and $ C_{2} $ compounds and $ N_{1} $ compounds (including $ C_{1} $$ N_{1} $ compunds such as HCN), probably through glycine, in the early stage of chemical evolution. Uracil, cytosine, and amino acids of the Pyrimidine Group may be regarded as synthesized directly or indirectly from three-carbon chain compounds. This synthesis became possible after the accumulation of three-carbon chain compounds and their derivatives in the primeval sea. The Purine Group can be further classified into a Guanine or (Gly+$ nC_{1} $) Subgroup and an Adenine or (Gly+$ nC_{2} $) Subgroup or simply $ nC_{2} $ Subgroup. The Pyrimidine Group can be further classified into a Uracil or $ C_{3} $$ C_{6} $$ C_{9} $ Subgroup and a Cytosine or $ C_{5} $-chain Subgroup (Table I). It is suggested that the primitive genetic code was established by a specific interaction between amino acids and their respective nucleotide bases. The interaction was dependent upon their concentration in the primeval environments and the binding constants between amino acids and their respective bases.


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    Title :

    A working hypothesis on the interdependent genesis of nucleotide bases, protein amino acids, and primitive genetic code


    Contributors:

    Published in:

    Publication date :

    1981




    Type of media :

    Article (Journal)


    Type of material :

    Print


    Language :

    English



    Classification :

    Local classification TIB:    535/3908/4290
    BKL:    44.71 Verkehrsmedizin



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