Abstract This paper is primarily a review of recent developments in the abiotic synthesis of nucleotides, short chain oligonucleotides, and their mode of replication in solution. It also presents preliminary results from this laboratory on the prebiotic synthesis of thymidine oligodeoxynucleotides. A discussion, based on the physicochemical properties of RNA and DNA oligomers relevant to the molecular evolution of these compounds leads to the tentative hypothesis that oligodeoxyribonucleotides of about 12 units may have been of sufficient length to initiate a self replication coding system. Two models are suggested to account for the synthesis of high molecular weight oligomers using short chain templates and primers.


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    Title :

    The prebiotic synthesis of oligonucleotides


    Contributors:

    Published in:

    Publication date :

    1974




    Type of media :

    Article (Journal)


    Type of material :

    Print


    Language :

    English



    Classification :

    BKL:    44.71 Verkehrsmedizin
    Local classification TIB:    535/3908/4290



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