Abstract Diiminosuccinonitrile (DISN) has been investigated as a potential prebiotic phosphorylating agent. It is formed readily by the oxidation of diaminomaleonitrile (DAMN), a tetramer of HCN, DISN effects the cyclization of 3′-adenosine monophosphate to adenosine 2′,3′-cyclic phosphate in up to 40% yield. The DISN-mediated phosphorylation of uridine to uridine monophosphate does not proceed efficiently in aqueous solution. The reaction of DISN and BrCN with uridine-5′-phosphate and uridine results in the formation of 2,2′-anhydronucleotides and 2,2′-anhydronucleosides respectively, and other reaction products resulting from an initial reaction at the 2′- and 3′-hydroxyl groups. The clay mineral catalysis of the cyclization of adenosine-3′-phosphate was investigated using homoionic montmorillonites.


    Access

    Check access

    Check availability in my library

    Order at Subito €


    Export, share and cite



    Title :

    Prebiotic synthesis and reactions of nucleosides and nucleotides


    Contributors:

    Published in:

    Publication date :

    1983-01-01


    Size :

    8 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



    Prebiotic synthesis and reactions of nucleosides and nucleotides

    Ferris, J. P. / Yanagawa, H. / Hagan, W. J., Jr. | NTRS | 1983


    The prebiotic chemistry of nucleotides

    Ferris, J. P. / Yanagawa, H. / Hagan, W. J. | Online Contents | 1984


    Prebiotic phosphorylation of nucleosides in formamide

    Schoffstall, Allen M. | Online Contents | 1976


    Interactions between amino acids and nucleotides in the prebiotic milieu

    Saxinger, Carl / Ponnamperuma, Cyril | Online Contents | 1974


    Prebiotic Synthesis of Nucleotides at the Earth Orbit in Presence of Lunar Soil

    Kuzicheva, E. A. / Gontareva, N. B. / The Committee on Space Research | British Library Conference Proceedings | 2002