Described herein are FasL-engineered biomaterials, as well as methods of making and using such FasL-engineered biomaterials, such as for immunomodulation, such as for inducing immunosuppression and specific immune tolerance, such as for preventing or reducing the risks of rejection of cellular or tissue grafts and/or the treatment of autoimmune disorders such as Type I diabetes. In specific embodiments, the FasL-engineered biomaterials are biotinylated microgels bound to SA-FasL.

    L'invention concerne des biomatériaux à modification FasL, ainsi que des procédés de fabrication et d'utilisation de tels biomatériaux à modification FasL, notamment pour l'immunomodulation, par exemple pour induire une immunosuppression et une tolérance immunitaire spécifique, notamment pour prévenir ou réduire les risques de rejet de greffes cellulaires ou tissulaires et/ou le traitement de troubles auto-immuns tels que le diabète de type I. Dans des modes de réalisation spécifiques, les biomatériaux à modification FasL sont des microgels biotinylés liés à SA-FasL.


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    Title :

    FASL-ENGINEERED BIOMATERIALS WITH IMMUNOMODULATORY FUNCTION


    Additional title:

    BIOMATERIAUX A MODIFICATION FASL AYANT UNE FONCTION IMMUNOMODULATRICE


    Contributors:
    SHIRWAN HAVAL (author) / GARCIA ANDRES J (author) / YOLCU ESMA S (author) / ZHAO HONG (author) / HEADEN DEVON (author)

    Publication date :

    2018-09-13


    Type of media :

    Patent


    Type of material :

    Electronic Resource


    Language :

    English


    Classification :

    IPC:    C12M APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY , Vorrichtungen für Enzymologie oder Mikrobiologie / A61K Zubereitungen für medizinische, zahnärztliche oder kosmetische Zwecke , PREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES / B60L PROPULSION OF ELECTRICALLY-PROPELLED VEHICLES , Antrieb von elektrisch angetriebenen Fahrzeugen / C12N Mikroorganismen oder Enzyme , MICROORGANISMS OR ENZYMES / G01N Untersuchen oder Analysieren von Stoffen durch Bestimmen ihrer chemischen oder physikalischen Eigenschaften , INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES



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