AbstractTo compare actual spaceflight to ground-based simulation (hindlimb-suspension), we measured the norepinephrine (NE) content in A1, A2, A5 and A6 (locus coeruleus) and the vasopressin content in the neurohypophysial system. The experimental period was of 9 days' duration. The NE content in the locus coeruleus decreased significantly in rats flown for 9 days (67 %,p<0.001), but showed no significant changes after hindlimb-suspension. These results demonstrated that suspended rats adapted better to weightlessness-simulation than flown rats to actual microgravity. In rats flown aboard SLS-1, the vasopressin content was significantly increased in the posterior pituitary (71 %,p<0.01), and was decreased in the hypothalamus (49 %, p<0.05). In 9-day suspended rats pituitary vasopressin levels were unchanged, while in the hypothalamus a significant decrease was noted (21 %, p<0.05). It was concluded that spaceflight changes in pituitary vasopressin levels and in the locus coeruleus NE content were consistent with a stress reaction, occurring during and/or after landing. These results confirmed that hindlimb-suspension model constitutes a valid and lesstressful ground-based simulation of microgravity in rats.


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    Title :

    Comparison of the effects of spaceflight and hindlimb-suspension on rat pituitary vasopressin and brainstem norepinephrine content


    Contributors:
    Fareh, J. (author) / Fagette, S. (author) / Cottet-Emard, J.M. (author) / Allevard, A.M. (author) / Viso, M. (author) / Gauquelin, G. (author) / Gharib, C. (author)

    Published in:

    Advances in Space Research ; 14 , 8 ; 365-371


    Publication date :

    1994-01-01


    Size :

    7 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



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