Abstract It is shown that the RBE of the 70 GeV proton secondary radiation for the induction of single-strand break is 1.6–7.6 in Chinese hamster fibroblasts and 1.04–3.8 in limphoid cells and for the lethality of Chinese hamster cells 1.14–1.7. The RBE value increases with decreasing dose of the secondary radiation. On post-irradiation incubation of mammalian cells at 37°C, single-strand breaks induced by the secondary radiation are repaired with the same time course as those induced by ▪-rays. In our earlier works we have made an attempt to estimate the biological efficiency of radiation generated by the 70 GeV protons on bacteria, phage T4 and Vicia faba beans /1,2,3/. The obtained values of the relative biological efficiency (RBE) of this radiation varied between 1.4 and 5.5, depending on the object, criterion of estimation, times of registration and other experimental conditions. The aim of the present work is to estimate the biological efficiency of synchrotron radiation by its effect on mammalian cells.


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    Title :

    Effect of secondary radiation produced by 70 GeV protons on DNA of mammalian cells


    Contributors:

    Published in:

    Advances in Space Research ; 4 , 10 ; 231-235


    Publication date :

    1984-01-01


    Size :

    5 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English





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