In this paper, we evaluate the closed-loop performance of two switching strategies for a dual-hormone artificial pancreas (AP). The dual-hormone AP administers insulin and glucagon subcutaneously. Since insulin and glucagon have opposite effects, we want to avoid simultaneous injections of these two hormones. To handle non-simultaneous injections of insulin and glucagon, we compare model predictive control (MPC) algorithms using a hysteresis switch between insulin and glucagon controllers with a multiple-input single-output (MISO) formulation. Although the closed-loop performance of these two control strategies is similar, the hysteresis switch is preferable due to (i) its greater flexibility in control design and tuning and (ii) a more straightforward way to avoid simultaneous injections of insulin and glucagon.
Design of Switched Model Predictive Control Algorithms for a Dual-Hormone Artificial Pancreas
2018-01-01
Boiroux , D , Bátora , V , Mahmoudi , Z & Jørgensen , J B 2018 , ' Design of Switched Model Predictive Control Algorithms for a Dual-Hormone Artificial Pancreas ' , I F A C Workshop Series , vol. 51 , no. 27 , pp. 174-179 . https://doi.org/10.1016/j.ifacol.2018.11.647
Article (Journal)
Electronic Resource
English
DDC: | 629 |
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