We present a simple control algorithm for a single-hormone artificial pancreas (AP). The AP consists of a continuous glucose monitor (CGM) measuring the interstitial glucose concentration, a control algorithm computing the insulin to administer, and an insulin pump dosing the insulin. The control algorithm is based on insights into the underlying dynamics of the glucose-insulin dynamics in people with type 1 diabetes. The main components in this control system are 1) an insulin bolus calculator to compensate for carbohydrates in meals, 2) a run-to-run algorithm for adjusting the basal insulin to long-term metabolic variations, and 3) a micro-bolus correction of the basal insulin to compensate for short-term variations in the endogenous insulin production and insulin sensitivity.
An artificial pancreas based on simple control algorithms and physiological insight
2019-01-01
Jørgensen , J B , Boiroux , D & Mahmoudi , Z 2019 , ' An artificial pancreas based on simple control algorithms and physiological insight ' , IFAC-PapersOnLine , vol. 52 , no. 1 , pp. 1018-1023 . https://doi.org/10.1016/j.ifacol.2019.06.196
Article (Journal)
Electronic Resource
English
DDC: | 629 |
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