We consider a system of nonlinear delay differential equations that describes the interaction between three competing cell populations: healthy, leukemic and anti-leukemia T cells involved in Chronic Myeloid Leukemia (CML) under treatment with Imatinib. The aim of this work is to establish which model parameters are the most important in the success or failure of leukemia remission under treatment using a sensitivity analysis of the model parameters. For the most significant parameters of the model which affect the evolution of CML disease during Imatinib treatment we try to estimate the realistic values using some experimental data. For these parameters, steady states are calculated and their stability is analyzed and biologically interpreted.
Parameter estimation and sensitivity analysis for a mathematical model with time delays of leukemia
ICNPAA 2016 WORLD CONGRESS: 11th International Conference on Mathematical Problems in Engineering, Aerospace and Sciences ; 2016 ; La Rochelle, France
AIP Conference Proceedings ; 1798 , 1
2017-01-27
10 pages
Conference paper
Electronic Resource
English
Parameter analysis for a mathematical model of the immune system in leukemia
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