We consider a system of nonlinear delay differential equations that describes the interaction between three competing cell populations: healthy, leukemic and anti-leukemia T cells involved in Chronic Myeloid Leukemia (CML) under treatment with Imatinib. The aim of this work is to establish which model parameters are the most important in the success or failure of leukemia remission under treatment using a sensitivity analysis of the model parameters. For the most significant parameters of the model which affect the evolution of CML disease during Imatinib treatment we try to estimate the realistic values using some experimental data. For these parameters, steady states are calculated and their stability is analyzed and biologically interpreted.


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    Titel :

    Parameter estimation and sensitivity analysis for a mathematical model with time delays of leukemia


    Beteiligte:
    Cândea, Doina (Autor:in) / Halanay, Andrei (Autor:in) / Rădulescu, Rodica (Autor:in) / Tălmaci, Rodica (Autor:in) / Sivasundaram, Seenith (Herausgeber:in)

    Kongress:

    ICNPAA 2016 WORLD CONGRESS: 11th International Conference on Mathematical Problems in Engineering, Aerospace and Sciences ; 2016 ; La Rochelle, France


    Erschienen in:

    Erscheinungsdatum :

    27.01.2017


    Format / Umfang :

    10 pages





    Medientyp :

    Aufsatz (Konferenz)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch



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