Multidrug resistance (MDR) - an extensive barrier for successful chemotherapies. Currently, P-gp inhibitors in chemotherapeutic treatments attained better results. This paper focuses on critical review which summarizes the clinical and computational significance of P-glycoprotein role in efficacy of drugs in tumor cells, breast cancer, and ovarian cancer along with challenges in the development of P-gp inhibitors towards anti-cancer therapy. This paper covers systematic review of various computational tools in predicting P-gp in human cells in the context of various cancers.
A Comprehensive Analysis of Prediction of P-Glycoprotein in Tumour Cells, Breast Cancer and Ovarian Cancer Using Machine Learning
02.12.2021
692912 byte
Aufsatz (Konferenz)
Elektronische Ressource
Englisch
Genetic analysis of breast and ovarian cancer
British Library Conference Proceedings | 1995
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