A series of oximes were constructed to simultaneously detect and detoxify organophosphorus-based nerve agents. They function as optical sensors employing the oxime reactivity and incorporating a beta-hydroxyl group to undergo an intramolecular cyclization from the intermediate oxime-organophosphorus species. The generated isoxazole produces an enhanced fluorescent signal that reports on the presence and destruction of the nerve agent.


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    Title :

    Hydroxy oximes as organophosphorus nerve agent sensors


    Contributors:

    Published in:

    Publication date :

    2009


    Size :

    3 Seiten, 4 Bilder, 3 Tabellen, 38 Quellen




    Type of media :

    Article (Journal)


    Type of material :

    Print


    Language :

    English