Objective: This report describes the extended follow-up of a cohort of 46 399 automobile manufacturing workers with potential exposure to metalworking fluids (MWF). The outcomes of interest were cancers of the esophagus, stomach, colon, rectum, liver, pancreas, larynx, skin, prostate, and brain, as well as leukemia. Additional follow-up increased the power to detect modest elevations in mortality rates in association specific types of MWF, including synthetic fluids not in widespread use until the 1970s. Methods: Standardized mortality ratios (SMR) were computed for the most recent 10 years of follow-up, as well as for the entire study period. Adjusted relative risks (RR) were estimated in Poisson regression models with categorical variables for cumulative exposure to each type of MWF and in proportional hazards models with continuous exposure variables. Results: Associations were found between straight MWF and esophageal, laryngeal and rectal cancer; soluble MWF and cancer of the esophagus, larynx, skin, and brain; synthetic MWF and cancer of the esophagus, liver, and prostate. The elevated RR values were modest in magnitude (1.5 to 2.0) values were increased for stomach, liver, and pancreatic cancer and also for leukemia in the last 10 years of follow-up. The SMF values were also elevated for stomach and liver cancer among the persons recently hired. Conclusions: The results provide further evidence that exposure to metalworking fluids causes workers in automobile manufacturing. Although airborne exposures declined over the study period, this study suggests that modest risk of several digestive cancers, as well as prostatic cancer and leukemia, may persist at current levels of exposure to water-based metalworking fluids.


    Access

    Access via TIB

    Check availability in my library

    Order at Subito €


    Export, share and cite



    Title :

    Exposure-response models based on extended follow-up of a cohort mortality study in the automobile industry


    Contributors:
    Eisen, E.A. (author) / Bardin, J. (author) / Gore, R. (author) / Woskie, S.R. (author) / Hallock, M.F. (author) / Monson, R.R. (author)


    Publication date :

    2001


    Size :

    10 Seiten, 1 Bild, 7 Tabellen, 29 Quellen



    Type of media :

    Article (Journal)


    Type of material :

    Print


    Language :

    English




    Mortality studies of machining-fluid exposure in the automobile industry

    Tolbert, P.E. / Eisen, E.A. / Pothier, L.J. et al. | Tema Archive | 1992




    Follow-up automobile spoiler adapting to whole automobile posture and automobile

    CHEN JIAGUO / ZHANG YINGCHUN / WANG ZIHU et al. | European Patent Office | 2022

    Free access

    Range-extended automobile energy management system and range-extended automobile

    TANG RUYI / ZHANG YANG / CAO HONGSHENG et al. | European Patent Office | 2024

    Free access