Skeletal muscle fiber atrophy occurs in response to states of unloading such as during spaceflight (Adams et al. 2003) and ground-based analogues such as hind limb suspension and spaceflight in rodents (Caiozzo et al. 1994, 1996) and bedrest in humans (Adams et al. 2003). Unloading-induced atrophy appears to involve both components of the protein balance equation, which is defined as the ratio of protein synthesis rate divided by the protein degradation rate (synthesis/degradation rate) (Thomason and Booth 1990). When the degradation rate exceeds the synthesis rate, net protein loss (atrophy) occurs. While the equation is rather simple, the mechanisms are rather complex. The research emphasis during the past 10–15 years has focused heavily on understanding the upstream events regulating these protein processes.


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    Title :

    Muscle Wasting in Space and Countermeasures



    Published in:

    Handbook of Bioastronautics ; Chapter : 116 ; 181-196


    Publication date :

    2021-08-17


    Size :

    16 pages




    Type of media :

    Article/Chapter (Book)


    Type of material :

    Electronic Resource


    Language :

    English





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