Conclusion The specificity of tRNA aminoacylation as well as the origin of the genetic code are far from being understood at the molecular and evolutionnary level. The “tRNA-tRNA interaction model” could provide a missing link for resolving both problems. The model suggests a direct chemical interaction between the nucleotides in the anticodon, and the amino acid (adenylate) to be transferred to the 3′-terminal adenosine, within the catalytic center (23). The experimental data reviewed here indicate that in many, but not all, systems the anticodon does play a major role during the aminoacylation and that the simultaneous binding of two tRNA molecules for aminoacylation (of only one of them) does not contradict enzymatic and crystallographic data (24).


    Access

    Access via TIB

    Check availability in my library

    Order at Subito €


    Export, share and cite



    Title :

    Origin of the genetic code and specificity of tRNA aminoacylation. A testable model


    Contributors:

    Published in:

    Publication date :

    1984




    Type of media :

    Article (Journal)


    Type of material :

    Print


    Language :

    English



    Classification :

    Local classification TIB:    535/3908/4290
    BKL:    44.71 Verkehrsmedizin




    On the stereoselective aminoacylation of RNA

    Usher, D. A. / Needels, M. C. | NTRS | 1984


    The origin of the genetic code

    Ishigami, Masahiro / Nagano, Kei | Online Contents | 1975


    Modular testable release mechanism

    ERIAN HANY F | European Patent Office | 2017

    Free access