Conclusion The specificity of tRNA aminoacylation as well as the origin of the genetic code are far from being understood at the molecular and evolutionnary level. The “tRNA-tRNA interaction model” could provide a missing link for resolving both problems. The model suggests a direct chemical interaction between the nucleotides in the anticodon, and the amino acid (adenylate) to be transferred to the 3′-terminal adenosine, within the catalytic center (23). The experimental data reviewed here indicate that in many, but not all, systems the anticodon does play a major role during the aminoacylation and that the simultaneous binding of two tRNA molecules for aminoacylation (of only one of them) does not contradict enzymatic and crystallographic data (24).
Origin of the genetic code and specificity of tRNA aminoacylation. A testable model
Origins of life ; 14 , 1-4
1984
Article (Journal)
English
Local classification TIB: | 535/3908/4290 | |
BKL: | 44.71 Verkehrsmedizin |
Aminoacyl-tRNA synthetase families and their significance to the origin of the genetic code
Online Contents | 1978
|On the stereoselective aminoacylation of RNA
NTRS | 1984
|The origin of the genetic code
Online Contents | 1975
|