We have identified and validated a spaceflight-associated microRNA (miRNA) signature that is shared by rodents and humans in response to simulated and real spaceflight and regulates vascular damage by simulated deep space radiation. In previous studies, we identified miRNAs that are predicted to regulate rodent responses to spaceflight in low-Earth orbit. Here we have validated the expression of key spaceflight-associated miRNAs in rodents reacting to simulated spaceflight conditions (exposure to ionizing radiation combined with simulated microgravity) and in astronaut samples from the NASA Twin Study. We demonstrate that this circulating miRNA siganture is conserved between these different species and will serve as an ideal biomarker to monitor increase health risk due to exposure to the space environment. Lastly, to demonstrate their physiological relevance, we have utilized antagomirs to target a subset of miRNAs from the spaceflight associated signature to successfully rescue simulated deep space radiation-mediated damage in human 3D vascular constructs. These results provide strong evidence to further develop a miRNA based countermeasure in astronauts.


    Access

    Access via TIB

    Check availability in my library


    Export, share and cite



    Title :

    Circulating miRNA Signature Predicts and Rescues Spaceflight Associated Health Risks


    Contributors:

    Conference:

    American Society for Gravitational and Space Research (ASGSR) 2020 Meeting ; 2020 ; Virtual, US


    Type of media :

    Conference paper


    Type of material :

    No indication


    Language :

    English