It has become apparent that spaceflight alters many immune responses. Among the regulatory components of the immune response that have been shown to be affected by spaceflight is the cytokine network. Spaceflight, as well as model systems of spaceflight, have been shown to affect the production and action of various cytokines including interferons, interleukins, colony stimulating factors, and tumor necrosis factors. These changes have been shown not to involve a general shutdown of the cytokine network but, rather, to involve selective alterations of specific cytokine functions by spaceflight. The full breadth of changes in cytokines induced by spaceflight, as well as mechanisms, duration, adaptation, reversibility, and significance to resistance to infection and neoplastic diseases, remains to be established.
The role of cytokines in immune changes induced by spaceflight
Journal of leukocyte biology ; 54 , 3
1993-09-01
Miscellaneous
No indication
English
NASA Discipline Number 18-10 , Aerospace Medicine , NASA Program Flight , Cosmos 2044 Project , NASA Program Space Physiology and Countermeasures , STS Shuttle Project , NASA Discipline Number 00-00 , Flight Experiment , NASA Discipline Regulatory Physiology , unmanned , NASA Experiment Number COS 2044-35 , Non-NASA Center , manned , Cosmos 1887 Project , short duration
Immune changes in test animals during spaceflight
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