Spermatogonial cell loss has been observed in rats flown on Space Lab 3, Cosmos 1887, Cosmos 2044 and in mice following irradiation with X-ray or with HZE particle beams. Spermatogonial loss is determined by cell counting in maturation stage-6 seminferous tubules. With the exception of iron, laboratory irradiation experiments (with mice) revealed a similar pattern of spermatogonial loss proportional to the radiation dose at levels less than 0.1 Gy. Helium and argon irradiation resulted in a 5-percent loss of spermatogonia after only 0.01 Gy exposure. Significant spermatogonial loss (45 percent) occurred at this radiation level with iron particle beams. The loss of spermatogonia during each spaceflight was less than 10 percent when compared to control (nonflight) animals.


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    Title :

    Comparative study of spermatogonial survival after X-ray exposure, high LET (HZE) irradiation or spaceflight


    Contributors:
    Sapp, W. J. (author) / Williams, C. S. (author) / Williams, J. W. (author) / Philpott, D. E. (author) / Kato, K. (author) / Miquel, J. M. (author) / Serova, L. (author)

    Published in:

    Publication date :

    1992-01-01



    Type of media :

    Miscellaneous


    Type of material :

    No indication


    Language :

    English





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