Abstract Spermatogonial cell loss has been observed in rats flown on Space Lab 3, Cosmos 1887, Cosmos 2044 and in mice following irradiation with X-ray or with high energy (HZE) particle beams. Spermatogonial loss is determined by cell counting in maturation stage 6 seminferous tubules. With the exception of Iron, laboratory irradiation experiments (with mice) revealed a similar pattern of spermatogonial loss proportional to the radiation dose at levels less than 0.1 Gy. Helium and Argon irradiation resulted in a 5% loss of spermatogonia after only 0.01 Gy exposure. However, significant spermatogonial loss (45%) occurred at this radiation level with Iron particle beams. The loss of spermatogonia during each space flight was less than 10% when compared to control (non-flight) animals. This loss, although small, was significant. Although radiation may be a contributing factor in the loss of spermatogonia during space flight, exposure levels, as determined by dosimetry, were not significant to account for the total cell loss observed.


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    Title :

    Comparative study of spermatogonial survival after X-ray exposure, high let (HZE) irradiation or spaceflight


    Contributors:
    Sapp, W.J. (author) / Philpott, D.E. (author) / Williams, C.S. (author) / Williams, J.W. (author) / Kato, K. (author) / Miquel, J.M. (author) / Serova, L. (author)

    Published in:

    Advances in Space Research ; 12 , 2-3 ; 179-189


    Publication date :

    1991-01-01


    Size :

    11 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English




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