An examination has been made of the function of the human carotid-cardiac baroreflex (CCB) under the influence of simulated microgravity, varying states of vascular volume, and acute exercise. Results have been obtained which suggest that acute fluid replacement prior to reentry may not reverse the impaired baroreflex associated with postflight hypotension. It is also noted that one bout of maximal exercise increased baroreflex sensitivity and buffer capacity through 24 hrs post exercise; these baroreflex changes were the opposite of those following head-down bedrest. Contributions of reduced blood volume and impaired CCB function to orthostatic hypotension following microgravity appear to be separate and additive, so that maximal exercise and fluid replacement could be a potent countermeasure against postflight hypotension.
Carotid-cardiac baroreflex - Relaxation with orthostatic hypotension following simulated microgravity and implications for development of countermeasures
Acta Astronautica ; 23
1991-01-01
Miscellaneous
No indication
English
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