In patients with early parkinsonism, misdiagnosis may occur in >30% of cases. This can have detrimental consequences clinically and in clinical trials. Dopamine transporter (DAT) SPECT imaging can help improve diagnostic accuracy.

    Objective:

    To describe characteristics of individuals initially diagnosed with idiopathic Parkinson’s disease (iPD) and with abnormal DAT SPECT imaging who had a change in diagnosis on follow-up.

    Methods:

    Data were obtained from the biomarker study Parkinson’s Progression Markers Initiative (PPMI). PPMI is a multicenter, observational study that enrolled 423 individuals with a diagnosis of iPD of ≤2 years duration and with abnormal DAT SPECT imaging. Participants were assessed at least annually, and diagnosis was documented by the site neurologist. Characteristics of those that had a change in diagnosis were compared to those with stable diagnosis.

    Results:

    390 subjects were included. Eight (2%) had a change in diagnosis. The diagnosis was changed to multiple system atrophy in 5 cases, dementia with Lewy bodies in 2, and corticobasal degeneration in 1. Revision of diagnosis occurred 2–5.2 years from enrollment. Mean motor score was higher (26.9 vs 20.6; p = 0.01), DAT binding lower (1.056 vs 1.406; p = 0.01), genetic risk score lower (–0.016 vs –0.022; p = 0.0470), and olfaction score higher (28.75 vs 22.05; p = 0.03) in those whose diagnosis changed compared to those who did not.

    Conclusion:

    Diagnosis remained stable in most individuals with early parkinsonism diagnosed with iPD and with abnormal DAT imaging. A small number had a revision in diagnosis. Clinical and biomarker abnormalities were greater at baseline in those whose diagnosis changed.


    Access

    Check access

    Check availability in my library

    Order at Subito €


    Export, share and cite



    Title :

    Revision of Diagnosis in Early Parkinsonism with Abnormal Dopamine Transporter Imaging


    Additional title:

    Revision of Diagnosis in Early Parkinsonism


    Contributors:

    Published in:

    Publication date :

    2019-04-03


    Size :

    8 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English




    Dopamine transporter, alcoholism and other diseases

    Goldman, David | Nature Publishing Group | 1995


    Dopamine transporter mutant mice in experimental neuropharmacology

    Gainetdinov, R. R. | British Library Conference Proceedings | 2008


    Metric classification of early Parkinsonism in the space of electroencephalographic features

    Obukhov, Y. V. / Malyuta, I. A. / Obukhov, K. Y. | British Library Online Contents | 2016



    Abnormal sound diagnosis system

    UEDA HIROSHI | European Patent Office | 2024

    Free access