AbstractLarge uncertainties are associated with estimates of equivalent dose and cancer risk for crews of longterm space missions. Biological dosimetry in astronauts is emerging as a useful technique to compare predictions based on quality factors and risk coefficients with actual measurements of biological damage in-flight. In the present study, chromosomal aberrations were analyzed in one Italian and eight Russian cosmonauts following missions of different duration on the MIR and the international space station (ISS). We used the technique of fluorescence in situ hybridization (FISH) to visualize translocations in chromosomes 1 and 2. In some cases, an increase in chromosome damage was observed after flight, but no correlation could be found between chromosome damage and flight history, in terms of number of flights at the time of sampling, duration in space and extra-vehicular activity. Blood samples from one of the cosmonauts were exposed in vitro to 6 MeV X-rays both before and after the flight. An enhancement in radiosensitivity induced by the spaceflight was observed.


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    Title :

    Biological dosimetry in Russian and Italian astronauts


    Contributors:
    Greco, O (author) / Durante, M (author) / Gialanella, G (author) / Grossi, G (author) / Pugliese, M (author) / Scampoli, P (author) / Snigiryova, G (author) / Obe, G (author)

    Published in:

    Advances in Space Research ; 31 , 6 ; 1495-1503


    Publication date :

    2002-11-01


    Size :

    9 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English




    Biological Dosimetry in Russian and Italian Astronauts

    Greco, O. / Durante, M. / Gialanella, G. et al. | British Library Conference Proceedings | 2003




    Astronauts

    NTRS | 1988