AbstractChromosome damage was assessed in human peripheral blood lymphocytes after in vitro exposure to 28Si (490 or 600MeV/n), 48Ti (1000MeV/n), or 56Fe (600, 1000, or 5000MeV/n). LET values for these ions ranged from 51 to 184keV/μm and doses ranged from 10 to 200cGy. The effect of either aluminum or polyethylene shielding on the induction of chromosome aberrations was investigated for each ion. After chromosomes were prematurely condensed using calyculin-A, chromosome exchanges were measured using fluorescence in situ hybridization (FISH) with whole chromosome probes in cells collected at G2 and at mitosis in first division post-irradiation. The yield of chromosome aberrations increased linearly with dose, and the relative biological effectiveness (RBE) for the primary beams, estimated from the initial slope of the dose–response curve for total chromosome exchanges with respect to γ-rays, ranged from 9 to 35. The RBE values increased with LET, reaching a maximum for the 600 MeV/n Fe ions with LET of 184keV/μm. When the LET of the primary beam was below about 100keV/μm, the addition of shielding material increased the effectiveness per unit dose. When the LET of the primary beam was greater than 100keV/μm, shielding decreased the effectiveness per unit dose.


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    Title :

    The influence of shielding on the biological effectiveness of accelerated particles for the induction of chromosome damage


    Contributors:

    Published in:

    Advances in Space Research ; 39 , 6 ; 1076-1081


    Publication date :

    2007-01-03


    Size :

    6 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English





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