AbstractApplication of the degeneration sensitive, cupric-silver staining method to brain sections of male Sprague-Dawley rats irradiated 4 days before sacrifice with 155 Mev protons, 2–8 Gy at 1 Gy/min (N=6) or 22–101Gy at 20 Gy/min (N=16) or with 18.6 Mev electrons, 32–67 Gy at 20 Gy/min (N=20), doses which elicit behavioral changes (accelerod or conditioned taste aversion), resulted in a display of degeneration of astrocyte-like cell profiles which were not uniformly distributed. Plots of ‘degeneration scores’ (counts of profiles in 29 areas) vs. dose for the proton and electron irradiations displayed a linear dose response for protons in the range of 2–8 Gy. In the 20–100 Gy range, for both electrons and protons the points were distributed in a broad band suggesting a saturation curve. The dose range in which these astrocyte-like profiles becomes maximal corresponds well with the dose range for the X-ray eradication of a subtype of astrocytes, ‘beta astrocytes‘.
Histologic effects of high energy electron and proton irradiation of rat brain detected with a silver-degeneration stain
Advances in Space Research ; 14 , 10 ; 443-451
1994-01-01
9 pages
Article (Journal)
Electronic Resource
English
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