Abstract A theoretical approach to the understanding of the biochemical mechanisms of indirect action of ionizing radiation on SV40 DNA in aqueous solution is presented. The extent of OH attack on the sugar moiety and bases has been calculated. A realistic model for the DNA (in B form) based on available X-ray diffraction data is used and specific reaction sites for the OH radicals are obtained. A Monte Carlo scheme is used to follow the diffusion and reaction of the OH radicals. Effects of track structure have been considered and the single strand break D 37 values for 14 MeV electrons (low-LET) and 670 MeV/u and 40 MeV/u neon particles are presented. Calculated results are in agreement with available experimental data. It has been found that regardless of the qualities of radiation, 80% of the OH attack on DNA is on the bases and 20% is on the deoxyribose. From probability considerations only, it appears that the number of double strand breaks varies linearly with dose.


    Access

    Check access

    Check availability in my library

    Order at Subito €


    Export, share and cite



    Title :

    Theoretical consideration of the chemical pathways for radiation-induced strand breaks


    Contributors:
    Chatterjee, A. (author) / Koehl, P. (author) / Magee, J.L. (author)

    Published in:

    Publication date :

    1987-01-01


    Size :

    9 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



    Strand Breaks in DNA Samples Induced with LASERIX

    Zielbauer, B. / Habib, J. / Kazamias, S. et al. | Springer Verlag | 2009


    Strand Breaks in DNA Samples Induced with LASERIX

    Zielbauer, B. / Habib, J. / Kazamias, S. et al. | British Library Conference Proceedings | 2009


    Heavy ion induced double strand breaks in bacteria and bacteriophages

    Micke, U. / Schäfer, M. / Anton, A. et al. | Elsevier | 1991


    Heavy ion induced DNA double strand breaks in cells of E. coli

    Schäfer, M. / Schmitz, C. / Bücker, H. | Elsevier | 1994