Highlights ► Spaceflight causes a thinning of the apical mucin layer of the mouse uterine tube. ► Spaceflight does not alter the pH of the mucin layer of the mouse uterine tube. ► Housing conditions affect the mucin layer of the mouse uterine tube.
Abstract Numerous studies have indicated that the microgravity environment of space has harmful effects on several tissues throughout the body. Although this phenomenon is well documented, research in this area is still in its relative infancy. This study investigates the effects of space flight on mucin production of the uterine tubes of mice. This study examined the epithelium of the uterine tubes from female mice that were flown on the space shuttle Endeavour for 13days in August, 2007 and their concomitant controls. The tissue was qualitatively analyzed for the type of mucin produced, i.e., acidic, neutral, acidic/neutral mixture. Further, the tissue was quantitatively analyzed for the amounts of mucins produced by measuring the thickness of the mucin layer for each region of the uterine tube: isthmus, ampulla, and infundibulum. One way ANOVA tests were used to compare mucin thickness between all three sets of animals. Results indicate similar but not identical results between the three regions of the uterine tube. The Baseline tissue had the thickest mucin layer regardless of treatment group. In the ampulla the mucin layer was the thinnest in the Flight tissue, followed by the Ground Control, with the Baseline being the thickest. Analysis of the mucin layer of the infundibulum of the three treatment groups indicated no difference in its thickness between the three regions of the uterine tube. These results indicate a trend toward thinning of the mucin layer of the uterine tube in space flight, but also indicate an influence by the housing environment.
The effect of the space flight environment on mucin production in the mouse uterine tube
Advances in Space Research ; 51 , 12 ; 2229-2234
2013-01-18
6 pages
Article (Journal)
Electronic Resource
English
Microgravity , Space flight , Mucin , Uterine tube , Oviduct , Ampulla
The effect of the space flight environment on mucin production in the mouse uterine tube
Online Contents | 2013
|Effect of space flight on cytokine production
Online Contents | 1994
|Effect of space flight on cytokine production
British Library Conference Proceedings | 1994
|SPACE PHYSICS- ENVIRONMENT FOR MANNED SPACE FLIGHT
NTRS | 1961
|Space Flight Environment and Biodynamic Forces
NTRS | 2022
|