Abstract The peculiarities and mechanisms of the mutagenic action of γ-rays and heavy ions on bacterial cells have been investigated. Direct mutations in the lac-operon of E. coli in wild type cells and repair deficient strains have been detected. Furthermore, the induction of revertants in Salmonella tester strains was measured. It was found that the mutation rate was a linear-quadratic function of dose in the case of both γ-rays and heavy ions with LET up to 200 keV/μm. The relative biological effectiveness (RBE) increased with LET up to 20 keV/μm. Low mutation rates were observed in repair deficient mutants with a block of SOS-induction. The induction of SOS-repair by ionizing radiation has been investigated by means of the “SOS-chromotest” and λ-prophage induction. It was shown that the intensity of the SOS-induction in E. coli increased with increasing LET up to 40–60 keV/μm.
Mutagenic effects of heavy ions in bacteria
Advances in Space Research ; 12 , 2-3 ; 103-110
1991-01-01
8 pages
Article (Journal)
Electronic Resource
English
Mutagenic Effects of Heavy Ions in Bacteria
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