Abstract This overview summarizes murine results on acute lethality responses, inactivation of marrow CFU-S and intestinal microcolonies, testes weight loss, life span shortening, and posterior lens opacification in mice irradiated with heavy charged particles. RBE-LET relationships for these mammalian responses are compared with results from studies. The trend is that the maximum RBE for responses tends to be lower and occurs at a lower LET than for inactivation of V79 and T-1 cells in culture. Based on inactivation cross sections, the response of CFU-S conforms to expectations from earlier studies with prokaryotic systems and mammalian cells in culture. Effects of heavy ions are compared with fission spectrum neutrons, and the results are consistent with the interpretation that RBEs are lower than for fission neutrons at about the same LET, probably due to differences in track structure. Issues discussed focus on challenges associated with assessments of early and late effects of charged particles based on dose, RBE and LET, and with the concordance or discordance of results obtained with and model systems. Models for radiation damage/repair and misrepair should consider effects observed with as well as model systems.
Early and late mammalian responses to heavy charged particles
Advances in Space Research ; 6 , 11 ; 153-165
1987-01-01
13 pages
Article (Journal)
Electronic Resource
English
Track Structure and the Calculation of Biological Effects of Heavy Charged Particles
British Library Conference Proceedings | 1995
|Track Structure and the Calculation of Biological Effects of Heavy Charged Particles
Online Contents | 1996
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