Abstract C3H 10T 1 2 mouse-embryo fibroblasts were used for transformation experiments to study the effectiveness of various heavy ions with energies up to 20 MeV/u and LET values from 170 to 16.000 keV/μm. The transformation frequency per unit absorbed dose decreased with increasing ionization density; at the highest values of LET we found a decrease even of the transformation efficiency per unit fluence. Uranium ions at energies of 5, 9, and 16.3 MeV/u did not induced any transformation. In additional studies piimary Syrian hamster embryo cells (SHE) were exposed to heavy ions in order to characterize cytological and molecular changes which may be correlated with neoplastic transformation. Growth behaviour, chromosomal status, tumorigenicity in nude mice, and expression of oncogenes of transformed cell lines were examined.


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    Title :

    Neoplastic transformation of mouse C3H 10T 1 2 and Syrian hamster embryo cells by heavy ions


    Contributors:
    Hieber, L. (author) / Ponsel, G. (author) / Trutschler, K. (author) / Fenn, S. (author) / Kellerer, A.M. (author)

    Published in:

    Advances in Space Research ; 9 , 10 ; 141-149


    Publication date :

    1989-01-01


    Size :

    9 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



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