PURPOSE: Dynamic CEST studies such as dynamic glucose enhanced imaging, have gained a lot of attention recently. The expected CEST effects after injection are rather small in tissue especially at clinical field strengths (0.5-2%). Small movements during the dynamic CEST measurement together with a subtraction-based evaluation can lead to pseudo CEST effects of the same order of magnitude. These artifacts are studied herein. METHODS: A brain tumor patient 3D-CEST baseline scan without glucose injection performed at 3 T is used to generate a virtual dynamic measurement introducing different kinds of simulated motion and B0 shifts. RESULTS: Minor motion (0.6 mm translations) and B0 artifacts (7 Hz shift) can lead to pseudo effects in the order of 1% in dynamic CEST imaging. Especially around tissue interfaces such as CSF borders or tumor affected areas, the pseudo effect patterns are non-intuitive and can be mistaken as dynamic agent uptake. CONCLUSION: Correction or mitigation for small motions is crucial for dynamic CEST imaging, especially in subjects with lesions. Concomitant B0 alterations can as well induce pseudo CEST effects at 3 T.


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    Title :

    Possible artifacts in dynamic CEST MRI due to motion and field alterations


    Contributors:
    Zaiss, M (author) / Herz, K (author) / Deshmane, A (author) / Kim, M (author) / Golay, X (author) / Lindig, T (author) / Bender, B (author) / Ernemann, U (author) / Scheffler, K (author)

    Publication date :

    2019-01-01


    Remarks:

    Journal of Magnetic Resonance , 298 pp. 16-22. (2019)


    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



    Classification :

    DDC:    629



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