Since its development in late 1960s, 45S5 Bioglass® is one of the most studied biomaterials for bone defect repair due to its property to bond with both soft and hard tissues and the capability to release ions overtime that have a positive effect on osteoblast gene activation. This material has been successfully used in clinical applications as particulates or monolithic, but porous 3D Bioglass® scaffolds are not yet available for clinical applications due to the relatively low mechanical properties associated to the high porosity (> 90%) of the constructs. The present work developed 45S5 Bioglass®-based foams via a replica method using natural marine sponges as sacrificial templates. The goal was to produce Bioglass®-based scaffolds with improved mechanical properties (up to 4 MPa) due to a reduction of the total porosity (68%) but without affecting the pore interconnectivity (> 99%), which plays a key role in cell ingrowth and neovascularization. Natural marine sponges, thanks to the millenarian evolution in water filtration, were considered adequate sacrificial template for production of bone tissue engineering scaffolds due to their efficient interconnected porous structure. The obtained scaffolds were characterized by high bioactivity and mechanical stability also after one month in simulated body fluid (SBF), achieving compressive strength values of 1.2 ± 0.2 MPa. In order to enhance even more the mechanical properties of these Bioglass® scaffolds based on natural marine sponges and to introduce functional ions and drug release capability, different functional coatings with ordered mesoporous materials were developed. The approach was to combine the bioactivity of the bioactive glass based scaffolds with the drug uptake and release capability of ordered mesoporous silica based materials. Ordered mesoporous silica particles, MCM-41 and MCM-41 doped with Ag (Ag_MCM-41), were synthetized and used as a functional coating with the effect of increasing the mechanical properties, up to 11 MPa, of the ...
Natural marine derived bioactive glass based scaffolds with improved functionalities ; Bioaktive glasbasierte Scaffolds aus Naturschwamm mit verbesserter Funktionalitaet
2017-01-01
Theses
Electronic Resource
English
DDC: | 629 |
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