Novel developments in the field of cardiac tissue engineering (CTE) are highly relevant and timely due to the massive number of cases worldwide involving mortality and morbidity caused by cardiovascular diseases (CVDs) every year. In particular after severe damage of the myocardial tissue, for example caused by myocardial infarction (MI), the infected area forms a fibrotic scar, which can lead to reduced contractility and thereby to congestive or chronic heart failure. Owing to the very limited intrinsic self-regeneration ability of cardiomyocytes, insufficient medical treatments available to date, the low availability of donor organs, and the time-limited application of ventricular assist devices, CTE represents an alternative approach to address the enormous clinical need by developing novel therapeutic measures like the cardiac patch strategy. The cardiac patch should mimic the myocardial extracellular matrix (ECM) as close as possible and, consequently, should not only be biocompatible and biodegradable but should also offer matching surface properties as well as chemical, mechanical, and electrical properties related to the native environment. Therefore, in the present thesis, novel biomaterials based on combinations of natural and synthetic polymers have been processed by electrospinning into fibrous scaffolds. Electrospinning was chosen for being a versatile and facile scaffold fabrication method, which allows the production of continuous fibers with diameters between tens of nano- to micrometer, resembling the fibrous myocardial ECM. Additionally, electrospun scaffolds offer high porosities formed by interconnected pores, very high surface area to volume ratio, superior mechanical characteristics, and flexibility in surface functionalities. Three different polymeric systems, namely gelatin/poly(glycerol sebacate) (PGS)/polyaniline (PANi), collagen/hyaluronic acid (HA)/PANi, and poly(ε-caprolactone) (PCL)/poly(1,8-octanediol-co-citrate) (POC) dip-coated with gelatin/PANi, were developed and characterized ...


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    Title :

    Development and Characterization of Biopolymer-Based Fibrous Scaffolds with Enhanced Functionality for Cardiac Tissue Engineering ; Entwicklung und Charakterisierung von Biopolymer-basierten Fasergerüsten mit erweiterter Funktionalität für das kardiale Tissue Engineering


    Contributors:
    Vogt, Lena (author)

    Publication date :

    2022-01-01


    Type of media :

    Theses


    Type of material :

    Electronic Resource


    Language :

    English


    Keywords :

    Classification :

    DDC:    629






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