We propose a whole-body model of the metabolism in man as well as a generalized approach for modeling metabolic networks. Using this approach, we are able to write a large metabolic network in a systematic and compact way. We demonstrate the approach using a whole-body model of the metabolism of the three macronutrients, carbohydrates, proteins and lipids. The model contains 7 organs, 16 metabolites and 31 enzymatic reactions. All reaction rates are described by Michaelis-Menten kineties with an addition of a hormonal regulator based on the two hormones insulin and glucagon. We incorporate ingestion of food in order to simulate metabolite concentrations during the feed-fast cycle. The model can simulate several days due to the inclusion of storage forms (glycogen, musele protein and lipid droplets), that can be depleted if food is not ingested regularly. A physiological model incorporating complex cellular metabolism and whole-body mass dynamics can be used in virtual clinical trials. Such trials can be used to improve the development of medicine, treatment strategies such as control algorithms, and increase the likelihood of a successful clinical trial.


    Access

    Download


    Export, share and cite



    Title :

    A whole-body multi-scale mathematical model for dynamic simulation of the metabolism in man



    Publication date :

    2022-01-01


    Remarks:

    Carstensen , P E , Bendsen , J , Reenberg , A T , Ritschel , T K S & Jorgensen , J B 2022 , ' A whole-body multi-scale mathematical model for dynamic simulation of the metabolism in man ' , IFAC-PapersOnLine , vol. 55 , no. 23 , pp. 58-63 . https://doi.org/10.1016/j.ifacol.2023.01.015



    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



    Classification :

    DDC:    629





    A detailed single-link track model for multi-body dynamic simulation of crawlers

    Rubinstein, Dror / Coppock, James L. | Elsevier | 2007


    A Detailed Multi-Body Model for Dynamic Simulation of Off-Road Tracked Vehicles

    Rubinstein, D. / Hitron, R. / International Society for Terrain-Vehicle Systems | British Library Conference Proceedings | 2002