For people with type 1 diabetes and some with type 2 diabetes, the problem of insulin titration, i.e. finding an adequate basal rate of insulin, is a complex and time-consuming task. This paper proposes a simple model-free algorithm and a procedure for fast initial titration in people with type 1 diabetes (T1D). A modified proportional-integral-derivative (PID) controller (i) updates the estimated insulin basal rate, and (ii) administers micro-boli of insulin every 5 minutes using glucose measurements from a continuous glucose monitor (CGM). A bolus calculator mitigates the effect of meals and reduces postprandial peaks. We evaluate the performance of our system qualitatively and numerically using a virtual clinic of 1,000 T1D patients with a broad inter-patient variability representative of a real population of people with T1D. We let the titration phase run for three consecutive days, followed by a three-day test phase using the newly computed basal insulin infusion rate. The proposed algorithm is able to provide a safe titration and individualized treatment for people with T1D.


    Access

    Download


    Export, share and cite



    Title :

    Initial titration for people with type 1 diabetes using an artificial pancreas



    Publication date :

    2021-01-01


    Remarks:

    Sejersen , M , Boiroux , D , Engell , S E , Ritschel , T K S , Reenberg , A T & Jørgensen , J B 2021 , ' Initial titration for people with type 1 diabetes using an artificial pancreas ' , IFAC-PapersOnLine , vol. 54 , no. 15 , pp. 484-489 . https://doi.org/10.1016/j.ifacol.2021.10.303



    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



    Classification :

    DDC:    629



    Event-Triggered Adaptive Disturbance Rejection for Artificial Pancreas

    Shi, Dawei / Huang, Yuan / Wang, Junzheng et al. | Springer Verlag | 2021


    Prevention of hypoglycaemic events in young people with type 1 diabetes

    Nordfeldt, S. / Ludvigsson, J. / International Association of Accident and Traffic Medicine | British Library Conference Proceedings | 2000


    Artificial pancreas: from control-to-range to control-to-target

    Incremona, Gian Paolo / Messori, Mirko / Toffanin, Chiara et al. | BASE | 2017

    Free access

    Pancreas Transplantation

    Sutherland, D. E. R. | British Library Conference Proceedings | 2001


    An artificial pancreas based on simple control algorithms and physiological insight

    Jørgensen, John Bagterp / Boiroux, Dimitri / Mahmoudi, Zeinab | BASE | 2019

    Free access