We have used a novel technique that quantifies minerals and electrolytes from smears of sublingual cells by x-ray microanalysis to monitor metabolic changes in bed rest subjects. Increases in intracellular calcium (Ca), phosphorus (P), and potassium (K) were characteristic of subjects whose exercise regimen was inadequate to maintain calcium metabolism. To test the effects of space flight on intracellular ions, we analyzed cells from 2-4 kg Rhesus monkeys before and after 2 weeks in space or chair restraint (CR). There were increases in sublingual cell Ca, P and K after space flight which paralleled the clinical estimates of metabolic status of the animals and exceeded the levels found during CR on R+11. Increases after 2 weeks CR were 26% in Ca, 6% in P and 29% in K. Species similarity ill responses of intracellular ions to inactivity imposed by bed rest, restraint or microgravity suggest that this innovative non-invasive technique would be a useful in-flight monitor of exercise countermeasures directed toward maintaining calcium balance.


    Zugriff

    Zugriff über TIB

    Verfügbarkeit in meiner Bibliothek prüfen


    Exportieren, teilen und zitieren



    Titel :

    Space Flight Effects on Intracellular Ions in Sublingual Cells of Non-Human Primates


    Beteiligte:
    Arnaud, Sara B. (Autor:in) / Dotsenko, R. (Autor:in) / Fung, P. (Autor:in) / Navidi, M. (Autor:in) / Silver, B. (Autor:in) / Wade, Charles E. (Autor:in)

    Kongress:

    65th Annual Scientific Meeting ; 1994 ; San Antonio, TX, United States


    Erscheinungsdatum :

    1994-01-01


    Medientyp :

    Aufsatz (Konferenz)


    Format :

    Keine Angabe


    Sprache :

    Englisch




    Microgravity Flight: Accommodating Non-Human Primates

    Dalton, Bonnie P. / Searby, Nancy / Ostrach, Louis | NTRS | 1995


    Microgravity Flight - Accommodating Non-Human Primates

    Dalton, Bonnie P. / Searby, Nancy / Ostrach, Louis | NTRS | 1994


    Microgravity Flight - Accommodating Non-Human Primates

    Dalton, Bonnie P. / Ostrach, Louis / Searby, Nancy | SAE Technical Papers | 1994


    Microgravity Flight - Accommodating Non-Human Primates

    Dalton, Bonnie P. / Searby, Nancy / Ostrach, Louis | NTRS | 1994


    Effects of space-flight simulation on human cells

    Villa, A. / Versari, S. / Barenghi, L. et al. | British Library Conference Proceedings | 2005