AbstractExperimental groups of male and female F1 (CBA×C57Bl/6) mice at the age of 3–4 months were exposed for 10 days to gamma irradiation (total dose 1.5cGy, dose rate 0.15cGy/day) or neutron irradiation (neutrons at average energy of 4.5MeV at a total neutron flux ranging from 105 to 106cm−2 and neutron flux density from 1 to 30cm−2s−1). These radiation doses were chosen so as to correspond to those received aboard spacecraft. [Mitrikas, V.G., Tsetlin, V.V., 2000. Radiation control onboard the MIR orbital manned station during the 22th solar cycle. Kosm. Issled. 38(2), 113–118.] Gamma irradiation stimulated the proliferation of femoral CFU-F, and their number increased by a factor of 1.5–4.5. The ectopic marrow grafts from γ-irradiated donors also increased in size. However, no changes in CFU-S proliferation rate and their number were observed. Neutron irradiation at a total absorbed dose of 2×10−1cGy (total neutron flux 2.8×107cm−2) produced a 1.5–3-fold increase in the number of femoral CFU-F, but that of CFU-S remained unchanged. At a lower total absorbed dose 0.82×10−2cGy, total neutron flux 1.3×106cm−2, the number of CFU-F remained at the control level. Therefore, the effect of radiation hormesis caused by neutron irradiation was observed at doses much lower than those of gamma irradiation.


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    Titel :

    Continuous gamma and neutron irradiation at low doses can increase the number of stromal progenitor cell (CFU-F) in mouse bone marrow


    Beteiligte:
    Domaratskaya, E.I. (Autor:in) / Tsetlin, V.V. (Autor:in) / Bueverova, E.I. (Autor:in) / Payushina, O.I. (Autor:in) / Butorina, N.N. (Autor:in) / Khrushchov, N.G. (Autor:in) / Starostin, V.I. (Autor:in)

    Erschienen in:

    Advances in Space Research ; 36 , 7 ; 1334-1339


    Erscheinungsdatum :

    2005-05-23


    Format / Umfang :

    6 pages




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch