AbstractExperimental groups of male and female F1 (CBA×C57Bl/6) mice at the age of 3–4 months were exposed for 10 days to gamma irradiation (total dose 1.5cGy, dose rate 0.15cGy/day) or neutron irradiation (neutrons at average energy of 4.5MeV at a total neutron flux ranging from 105 to 106cm−2 and neutron flux density from 1 to 30cm−2s−1). These radiation doses were chosen so as to correspond to those received aboard spacecraft. [Mitrikas, V.G., Tsetlin, V.V., 2000. Radiation control onboard the MIR orbital manned station during the 22th solar cycle. Kosm. Issled. 38(2), 113–118.] Gamma irradiation stimulated the proliferation of femoral CFU-F, and their number increased by a factor of 1.5–4.5. The ectopic marrow grafts from γ-irradiated donors also increased in size. However, no changes in CFU-S proliferation rate and their number were observed. Neutron irradiation at a total absorbed dose of 2×10−1cGy (total neutron flux 2.8×107cm−2) produced a 1.5–3-fold increase in the number of femoral CFU-F, but that of CFU-S remained unchanged. At a lower total absorbed dose 0.82×10−2cGy, total neutron flux 1.3×106cm−2, the number of CFU-F remained at the control level. Therefore, the effect of radiation hormesis caused by neutron irradiation was observed at doses much lower than those of gamma irradiation.
Continuous gamma and neutron irradiation at low doses can increase the number of stromal progenitor cell (CFU-F) in mouse bone marrow
Advances in Space Research ; 36 , 7 ; 1334-1339
2005-05-23
6 pages
Article (Journal)
Electronic Resource
English
British Library Conference Proceedings | 2005
|British Library Conference Proceedings | 2004
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