Electrical neurostimulation is effective in the treatment of neurological disorders, but associated recording artefacts generally limit its applications to open-loop stimuli. Real-time and continuous closed-loop control of brain activity can, however, be achieved by pairing concurrent electrical recordings and optogenetics. Here we show that closed-loop optogenetic stimulation with excitatory opsins enables the precise manipulation of neural dynamics in brain slices from transgenic mice and in anaesthetized non-human primates. The approach generates oscillations in quiescent tissue, enhances or suppresses endogenous patterns in active tissue and modulates seizure-like bursts elicited by the convulsant 4-aminopyridine. A nonlinear model of the phase-dependent effects of optical stimulation reproduced the modulation of cycles of local-field potentials associated with seizure oscillations, as evidenced by the systematic changes in the variability and entropy of the phase-space trajectories of seizures, which correlated with changes in their duration and intensity. We also show that closed-loop optogenetic neurostimulation could be delivered using intracortical optrodes incorporating light-emitting diodes. Closed-loop optogenetic approaches may be translatable to therapeutic applications in humans.


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    Titel :

    Closed-loop optogenetic control of the dynamics of neural activity in non-human primates


    Beteiligte:
    Zaaimi, B (Autor:in) / Turnbull, M (Autor:in) / Hazra, A (Autor:in) / Wang, Y (Autor:in) / Gandara, C (Autor:in) / McLeod, F (Autor:in) / McDermott, EE (Autor:in) / Escobedo-Cousin, E (Autor:in) / Idil, AS (Autor:in) / Bailey, RG (Autor:in)

    Erscheinungsdatum :

    2023-04-01


    Anmerkungen:

    Nature Biomedical Engineering , 7 pp. 559-575. (2023)


    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Elektronische Ressource


    Sprache :

    Englisch



    Klassifikation :

    DDC:    629



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