Due to their tunable solubility, phosphate-based glasses (PBG) also in the form of phosphate glass fibres (PGF), are gaining increasing attention as materials for medical applications representing an interesting alternative to antibiotics. A controlled release of ions from the glass can result in improved biological properties or bring antibacterial capability. In the presented studies, a modified melt quenching method delivered phosphate-based glasses based on the quaternary system P2O5–CaO–Na2O–MgO. In order to impact antibacterial properties, cerium oxide (CeO2) and gallium oxide (Ga2O3) were incorporated into the glass matrix. Later, two glass compositions were used to manufacture cerium-doped and gallium-doped phosphate glass fibres (Ce-PGF and Ga-PGF). The physicochemical and biological properties of novel PBG and PGF were characterised using several techniques. The structure of the glasses was analysed using Raman, Fourier Transorm Infrared Spectroscopy (FTIR), Differential scanning calorimetry (DSC), X-ray powder fluorescence (XRF) and X-ray powder diffraction (XRD) techniques. Correlations between the glass composition and its structure were found, showing an impact of gallium and cerium inclusion into the glass matrix. Addition of Ga and Ce has shown to increase glass transition temperature and processing windows. The XRD confirmed the amorphous character of the novel phosphate-based glasses. Moreover, the dissolution behaviour, surface charge (measured by zeta potential), ion release and pH were shown to depend on elemental composition. In particular the relative amounts of Ca and Mg showed a vast influence on the glass dissolution behaviour. The dissolution rate increase with an increase of magnesium content and decrease with an increase of calcium amount. A bioactivity test in simulated body fluid (SBF) did not confirm the bioactive properties of PBG and PGF. The mechanical properties performed using a single fibre tensile test method showed tensile strengths of 428 (±94) and 379 (±74) MPa and ...


    Zugriff

    Download


    Exportieren, teilen und zitieren



    Titel :

    Bioaktive Phosphatgläser ; Bioactive Phosphate Glasses


    Beteiligte:
    Lapa, Agata (Autor:in)

    Erscheinungsdatum :

    2020-01-01


    Medientyp :

    Hochschulschrift


    Format :

    Elektronische Ressource


    Sprache :

    Englisch


    Schlagwörter :

    Klassifikation :

    DDC:    629