Space travel and long-term space residence such as envisaged in the exploration era implicates burdens on the immune system. An optimal immune response is required to counteract and withstand exposure to pathogens. Countermeasure development is an important avenue in space research especially for long-term space exploration. Microgravity exposure causes detrimental effects in lymphocyte functions which may impair immune response. Impaired lymphocyte function can be remedied by bypassing cell membrane events. This is done by using compounds such as phorbol myristate acetate (PMA). Since activation in mouse splenocytes was augmented using nucleotides, it was essential to observe their effects on human lymphocyte locomotion. A nucleotide/nucleoside (NT/NT) mixture from Otsuka Pharmaceuticals (Naruto, Japan) was used at recommended doses. In lymphocytes cultured in modeled microgravity, the NT/NT mixture used orchestrated locomotion recovery by more than 87%, similar to the response documented with PMA in lymphocytes. Both 12 micro M and 120 micro M doses worked similarly. These are preliminary results leading to the possible use of the NT/NT mixture to mitigate immune suppression in microgravity. More studies in this direction are required to delineate the role of NT/NT on the immune response in microgravity.


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    Title :

    The role of nucleotides in augmentation of lymphocyte locomotion: Adaptional countermeasure development in microgravity analog environments


    Additional title:

    Die Rolle von Nukleotiden bei der Verstärkung der Lymphozyten-Beweglichkeit: Entwicklung adaptiver Gegenmaßnahmen in Mikrogravitäts-analogen Umgebungen


    Contributors:


    Publication date :

    2006


    Size :

    3 Seiten, 3 Bilder, 9 Quellen




    Type of media :

    Conference paper


    Type of material :

    Print


    Language :

    English




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