Abstract Possible formation of a $ P_{4} $$ O_{10} $ molecule in magma, the stability of the molecule in hydrous volcanic gas at high temperatures and a possible prebiotic phosphate cycle were discussed in relation to chemical evolution. To demonstrate the utility of phosphorus pentoxide as a phosphorylating agent, aqueous solutions of adenosine (0.02M) and phosphorus pentoxide (0.2M) were incubated at 37°C for 5 months. The pH of the solutions was adjusted every day or every few days to each fixed value (9.0, 10.5, 11.5, 12.5) with 10 N NaOH. The HPLC analysis showed the formation of 2′-AMP, 3′-AMP, 5′-AMP, cyclic (2′–3′)-AMP and cyclic (3′–5′)-AMP. The main components of the products were 2′- and 3′-AMP, though cyclic (2′–3′)-AMP was the main component in the early period of the incubation at pH 9.0. The yields (conversion rate of adenosine to AMPs) were increased almost linearly with the incubation time for 5 months in the case of pH 9.0. The final yields were about 3% (pH 9.0), 6% (pH 9.0, 1 M NaCl), 5% (pH 9.0, 0.01 M $ CaCl_{2} $, 0.01 M $ MgCl_{2} $), 7% (pH 9.0, 0.5 M NaCl, 0.01 M $ CaCl_{2} $, 0.01 M $ MgCl_{2} $), 9% (pH 9.0, 1 M NaCl, 0.01 M $ CaCl_{2} $, 0.01 M $ MgCl_{2} $), 32% (pH 10.5), 43% (pH 11.5), 35% (pH 12.5).


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    Title :

    AMP synthesis in aqueous solution of adenosine and phosphorus pentoxide


    Contributors:
    Yamagata, Y. (author) / Kojima, H. (author) / Ejiri, K. (author) / Inomata, K. (author)

    Published in:

    Publication date :

    1982




    Type of media :

    Article (Journal)


    Type of material :

    Print


    Language :

    English



    Classification :

    Local classification TIB:    535/3908/4290
    BKL:    44.71 Verkehrsmedizin