The rotating chair test, a novel research technique for simulating motion sickness, is used to study the effect of nonsedating oral antihistamines in preventing or forestalling motion sickness. After receiving terfenadine, astemizole, doxepin, or placebo, four groups of male volunteers were rotated at accelerating speed, and they made head movements out of the axis of rotation until they perceived that vomiting would occur if additional head movements were made. Those pretreated with doxepin or terfenadine experienced a statistically significant prophylactic effect, as measured by increased tolerance to Coriolis stimulation. This suggests that selective peripheral H1 antihistamine action may protect against motion sickness.
Is there a role for nonsedating antihistamines in motion sickness? Fallout from space research may soon benefit your patients
The Journal of respiratory diseases ; 12 , 4 Suppl
1991-04-01
Miscellaneous
No indication
English
NTRS | 1986
|NTRS | 1979
|Elsevier | 1978
|Research opportunities in space motion sickness, phase 2
NTRS | 1983
|Research opportunities in space motion sickness, phase 2
NTRS | 1983
|