The present disclosure relates to methods and compositions for treating cancer with a diaryl macrocycle in combination with an inhibitor of MAPK/ERK kinase-1 and -2 (MEK1 and MEK2; MAP2K1 and MAP2K2), such as trametinib.

    La présente invention concerne des méthodes et des compositions pour le traitement du cancer avec un macrocycle de diaryle en combinaison avec un inhibiteur de la kinase MAPK/ERK -1 et -2 (MEK1 et MEK2 ; MAP2K1 et MAP2K2), tel que le tramétinib.


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    Title :

    COMBINATION THERAPY INVOLVING DIARYL MACROCYCLIC COMPOUNDS


    Additional title:

    POLYTHÉRAPIE IMPLIQUANT DES COMPOSÉS MACROCYCLIQUES DE DIARYLE


    Contributors:
    DENG WEI (author) / ZHAI DAYONG (author) / RODON LAURA (author) / MURRAY BRION W (author) / CUI JINGRONG J (author) / LEE NATHAN V (author)

    Publication date :

    2021-06-03


    Type of media :

    Patent


    Type of material :

    Electronic Resource


    Language :

    English


    Classification :

    IPC:    B60H ARRANGEMENTS OR ADAPTATIONS OF HEATING, COOLING, VENTILATING, OR OTHER AIR-TREATING DEVICES SPECIALLY FOR PASSENGER OR GOODS SPACES OF VEHICLES , Anordnung oder Einbau der Heizung, Kühlung, Lüftung oder anderer Luftbehandlungsvorrichtungen für die Fahrzeugräume für Reisende oder Fracht / F24F Klimatisierung , AIR-CONDITIONING / F25B Kältemaschinen, Kälteanlagen oder Kälteverfahren , REFRIGERATION MACHINES, PLANTS, OR SYSTEMS



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