AbstractMale and female mice were subjected to rotationally-generated hypergravity of different duration (1 or 2h) and linear acceleration (2 or 1.08G). Pica behaviour and spontaneous activity were investigated before, during, and after rotation. Moreover, hole-board and plus-maze tests were performed 20min and 24h after the end of rotation. Pica behaviour arose in the post-rotation days and was more pronounced after 1h of 2G exposure. Spontaneous activity was almost or totally suppressed during rotation and failed to regain the pre-rotational levels in the group exposed to 2G for 1h. Exploratory behaviour in the hole-board was also impaired. A clear effect of hypergravity exposure emerged in the plus maze, with 2G mice totalizing a minor number of arm entries than the other groups and also showing an altered emotional/anxiety profile. Generally, females were more susceptible than males to the changes in gravitational environment.


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    Title :

    Behavioural responses to hypergravity in the CD-1 mouse


    Contributors:
    Francia, N. (author) / Corazzi, G. (author) / Petruzzi, S. (author) / Santucci, D. (author) / Alleva, E. (author)

    Published in:

    Acta Astronautica ; 58 , 8 ; 401-410


    Publication date :

    2005-12-08


    Size :

    10 pages




    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English





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