Electrical neurostimulation is effective in the treatment of neurological disorders, but associated recording artefacts generally limit its applications to open-loop stimuli. Real-time and continuous closed-loop control of brain activity can, however, be achieved by pairing concurrent electrical recordings and optogenetics. Here we show that closed-loop optogenetic stimulation with excitatory opsins enables the precise manipulation of neural dynamics in brain slices from transgenic mice and in anaesthetized non-human primates. The approach generates oscillations in quiescent tissue, enhances or suppresses endogenous patterns in active tissue and modulates seizure-like bursts elicited by the convulsant 4-aminopyridine. A nonlinear model of the phase-dependent effects of optical stimulation reproduced the modulation of cycles of local-field potentials associated with seizure oscillations, as evidenced by the systematic changes in the variability and entropy of the phase-space trajectories of seizures, which correlated with changes in their duration and intensity. We also show that closed-loop optogenetic neurostimulation could be delivered using intracortical optrodes incorporating light-emitting diodes. Closed-loop optogenetic approaches may be translatable to therapeutic applications in humans.


    Access

    Download


    Export, share and cite



    Title :

    Closed-loop optogenetic control of the dynamics of neural activity in non-human primates


    Contributors:
    Zaaimi, B (author) / Turnbull, M (author) / Hazra, A (author) / Wang, Y (author) / Gandara, C (author) / McLeod, F (author) / McDermott, EE (author) / Escobedo-Cousin, E (author) / Idil, AS (author) / Bailey, RG (author)

    Publication date :

    2023-04-01


    Remarks:

    Nature Biomedical Engineering , 7 pp. 559-575. (2023)


    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



    Classification :

    DDC:    629



    Multifunctional Neural Interfaces for Closed-Loop Control of Neural Activity

    Chapman, CAR / Goshi, N / Seker, E | BASE | 2018

    Free access


    Closed-Loop Control of HCCI Engine Dynamics

    Bengtsson, Johan | BASE | 2004

    Free access

    Closed-loop engine control

    Niepoth, G.W. / Stonestreet, S.P. | Tema Archive | 1977


    Hydraulic closed loop control

    Elfving, Maria | BASE | 2018

    Free access