Aim: In children, gait and posture assessment provides a crucial marker for the early characterization, surveillance and treatment evaluation of early onset ataxia (EOA). For reliable data entry of studies targeting at gait and posture improvement, uniform quantitative biomarkers are necessary. Until now, the pediatric test construct of gait and posture scores of the Scale for Assessment and Rating of Ataxia sub-scale (SARA) is still unclear. In the present study, we aimed to validate the construct validity and reliability of the pediatric (SARA(GAIT/POSTURE)) sub-scale. Methods: We included 28 EOA patients [15.5 (6-34) years; median (range)]. For inter-observer reliability, we determined the ICC on EOA SARA(GAIT/POSTURE) subscores by three independent pediatric neurologists. For convergent validity, we associated SARA(GAIT/POSTURE) sub-scores with: (1) Ataxic gait Severity Measurement by Klockgether (ASMK; dynamic balance), (2) Pediatric Balance Scale (PBS; static balance), (3) Gross Motor Function Classification Scale-extended and revised version (GMFCSE& R), (4) SARA-kinetic scores (SARA(KINETIC); kinetic function of the upper and lower limbs), (5) Archimedes Spiral (AS; kinetic function of the upper limbs), and (6) total SARA scores (SARA(TOTAL); i.e., summed SARA(GAIT/POSTURE), SARA(KINETIC), and SARA(SPEECH) sub-scores). For discriminant validity, we investigated whether EOA co-morbidity factors (myopathy and myoclonus) could influence SARA(GAIT/POSTURE) sub-scores. Results: The inter-observer agreement (ICC) on EOA SARA(GAIT/POSTURE) sub-scores was high (0.97). SARA(GAIT/POSTURE) was strongly correlated with the other ataxia and functional scales [ASMK (r(s) = -0.819; p <0.001); PBS (r(s) = -0.943; p <0.001); GMFCS-E& R (rs = -0.862; p <0.001); SARA(KINETIC) (r(s) = 0.726; p <0.001); AS (r(s) = 0.609; p = 0.002); and SARATOTAL (rs = 0.935; p <0.001)]. Comorbid myopathy influenced SARA(GAIT/POSTURE) scores by concurrent muscle weakness, whereas comorbid myoclonus predominantly ...


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    Title :

    Construct Validity and Reliability of the SARA Gait and Posture Sub-scale in Early Onset Ataxia



    Publication date :

    2017-12-13


    Remarks:

    Lawerman , T F , Brandsma , R , Verbeek , R J , van der Hoeven , J H , Lunsing , R J , Kremer , H P H & Sival , D A 2017 , ' Construct Validity and Reliability of the SARA Gait and Posture Sub-scale in Early Onset Ataxia ' , Frontiers in Human Neuroscience , vol. 11 , 605 . https://doi.org/10.3389/fnhum.2017.00605



    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



    Classification :

    DDC:    629





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