Nanotechnology provides a new design paradigm for alternative antibacterial strategies in the fight against drug-resistant bacteria. In this paper, the enhanced bactericidal action of moth-eye nanocomposite surfaces with a collaborative nanoparticle functional and topography structural mode of action is reported. The moth-eye nanocomposite surfaces are fabricated in combined processing steps of nanoparticle coating and surface nanoimprinting enabling the production of safer-by-design nanoparticle based antibacterial materials whereby the nanoparticle load is minimized whilst bactericidal efficiency is improved. The broad antibacterial activity of the nanocomposite moth-eye topographies is demonstrated against Gram-positive Staphylococcus aureus and Gram-negative Escherichia coli and Pseudomonas aeruginosa as model bacteria. The antibacterial performance of the moth-eye nanocomposite topographies is notably improved over that of the neat moth-eye surfaces with bacteria inhibition efficiencies up to 90%. Concurrently, the moth-eye nanocomposite topographies show a non-cytotoxic behaviour allowing for the normal attachment and proliferation of human keratinocytes. ; N


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    Title :

    Nano-engineering safer-by-design nanoparticle based moth-eye mimetic bactericidal and cytocompatible polymer surfaces



    Publication date :

    2018-06-20


    Remarks:

    oai:zenodo.org:1322035
    RSC Advances 2018 8 22606-22616



    Type of media :

    Article (Journal)


    Type of material :

    Electronic Resource


    Language :

    English



    Classification :

    DDC:    629




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