A finite element model of cerebral contusion in the rat was developed and compared to experimental injury maps demonstrating blood-brain barrier (BBB) breakdown. The model was exercised at the nine unique loading conditions used experimentally. Logistic regressions of four variables, maximum principal logarithmic strain (LEP), maximum principal stress (SP), strain energy density (SEN), and von Mises stress (MIS) demonstrated highly significant confidence in the prediction of the 50th percentile values (chi-squared, p<0.00001). However, only values for LEP were invariant across loading conditions. These results suggest that the BBB is most sensitive to LEP, and that breakdown occurs above a strain of 0.188 +/- 0.0324.


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    Titel :

    In Vivo Thresholds for Mechanical Injury to the Blood-Brain Barrier


    Weitere Titelangaben:

    Sae Technical Papers


    Beteiligte:

    Kongress:

    41st Stapp Car Crash Conference ; 1997



    Erscheinungsdatum :

    12.11.1997




    Medientyp :

    Aufsatz (Konferenz)


    Format :

    Print


    Sprache :

    Englisch


    Schlagwörter :


    In Vivo Thresholds for Mechanical Injury to the Blood-Brain Barrier

    Shreiber, D. I. / Bain, A. C. / Meaney, D. F. et al. | British Library Conference Proceedings | 1997


    In vivo thresholds for mechanical injury to the blood-brain barrier

    Shreiber,D.I. / Bain,A.C. / Meaney,D.F. et al. | Kraftfahrwesen | 1997


    Thresholds for Mechanical Injury to the in Vivo White Matter

    Bain, Allison C. / Meaney, David F. / University of Pennsylvania | SAE Technical Papers | 1999


    Thresholds for Mechanical Injury to the In Vivo White Matter

    Bain, A. C. / Meaney, D. F. / SAE | British Library Conference Proceedings | 1999


    Thresholds for mechanical injury to the in vivo white matter

    Bain,A.C. / Meaney,D.F. / Univ.of Pennsylvania,US | Kraftfahrwesen | 1999