Abstract A model is proposed for the early evolution of the coding mechanism. A primordial RNA embodies the functions of today's nucleic acids in a single molecule. The molecule is generated by successive rounds of self-priming and-templating. After proximity is assured by enclosure in a cell, the functions can be partitioned among more efficient specializel molecules. The prediction of sequence homologies in later forms prompted a search for matches between t- and r-RNAs. These are described. Their distributions offer clues to their origins. The existance of overlapping homologies indicates an approach to the reconstruction of an ancestral molecule.


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    Titel :

    tRNA-rRNA sequence homologies: A model for the origin of a common ancestral molecule, and prospects for its reconstruction


    Beteiligte:
    Bloch, David (Autor:in) / McArthur, Barbara (Autor:in) / Widdowson, Robert (Autor:in) / Spector, Deborah (Autor:in) / Guimaraes, Romeu C. (Autor:in) / Smith, Jean (Autor:in)

    Erschienen in:

    Erscheinungsdatum :

    1984




    Medientyp :

    Aufsatz (Zeitschrift)


    Format :

    Print


    Sprache :

    Englisch



    Klassifikation :

    Lokalklassifikation TIB:    535/3908/4290
    BKL:    44.71 Verkehrsmedizin



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